You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions.Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea sweating changes in your mood irritability and agitation dizziness electric shock feeling tremor anxiety confusion headache tiredness problems sleeping hypomania ringing in your ears seizures.Symptoms may include: greatly increased energy racing thoughts unusually grand ideas talking more or faster than usual severe problems sleeping reckless behavior excessive happiness or irritability. Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX.Tell your doctor right away about any unusual bleeding or bruising. Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk.Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation seeing or hearing things that are not real confusion coma fast heart beat changes in blood pressure dizziness sweating flushing high body temperature shaking, stiff muscles, or muscle twitching loss of coordination seizures nausea, vomiting, diarrhea. Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines.TRINTELLIX may cause serious side effects, including: What are the possible side effects of TRINTELLIX? John’s Wort medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin and diuretics. Especially tell your doctor if you take: medicines for migraine headache called triptans tricyclic antidepressants opioids (such as fentanyl and tramadol) lithium tryptophan buspirone St. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together.
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